Published on December 20, 2007
Exhibit
      5.1
    
S ICHENZIA R OSS F RIEDMAN F ERENCE LLP
    61
      BROADWAY, NEW YORK NY 10006
    TEL
      212 930 9700 FAX 212 930 9725 WEB WWW. SRFF.COM
    December
      20, 2007
    VIA
      ELECTRONIC TRANSMISSION
    Securities
      and Exchange Commission
    450
      Fifth
      Street, N.W.
    Washington,
      DC 20549
    
   
      Form
      SB-2 Registration Statement
    Ladies
      and Gentlemen:
    We
      refer
      to the above-captioned registration statement on Form SB-2 (the “Registration
      Statement”) under the Securities Act of 1933, as amended (the “Act”), filed by
      CryoPort, Inc., a Nevada corporation (the “Company”), with the Securities and
      Exchange Commission in connection with the registration of up to 14,571,392
      shares of the Company’s common stock.
    We
      have
      examined the originals, photocopies, certified copies or other evidence of
      such
      records of the Company, certificates of officers of the Company and public
      officials, and other documents as we have deemed relevant and necessary as
      a
      basis for the opinion hereinafter expressed. In such examination, we have
      assumed the genuineness of all signatures, the authenticity of all documents
      submitted to us as certified copies or photocopies and the authenticity of
      the
      originals of such latter documents.
    
Based
      on
      our examination mentioned above, we are of the opinion that the securities
      being
      sold pursuant to the Registration Statement are duly authorized are, or will
      be,
      when issued in the manner described in the Registration Statement, legally
      and
      validly issued, fully paid and non-assessable under the laws of the State of
      Nevada, including statutory provisions, all applicable provisions under the
      Nevada state constitution, and reported judicial decisions interpreting those
      laws.
    We
      hereby
      consent to the filing of this opinion as Exhibit 5.1 to the Registration
      Statement and to the reference to our firm under “Legal Matters” in the related
      Prospectus. In giving the foregoing consent, we do not hereby admit that we
      are
      in the category of persons whose consent is required under Section 7 of the
      Act,
      or the rules and regulations of the Securities and Exchange
      Commission.
    /s/
      SICHENZIA ROSS FRIEDMAN FERENCE LLP