Published on January 26, 2006
CRYOPORT
      SYSTEMS, INC.
    STOCK
      OPTION AGREEMENT
    (INCENTIVE
      STOCK OPTION)
    
This
      Stock Option Agreement (the “Agreement”) is made and entered into effective as
      of the date set forth on the Signature Page attached hereto by and between
      Cryoport Systems, Inc., a California corporation (the “Company”), and that
      person identified on the Signature Page attached hereto (the “Optionee”). This
      option is intended to qualify as an “incentive stock option” within the meaning
      of Section 422 of the Internal Revenue Code, as amended (the
“Code”).
    
The
      grant
      hereunder is in connection with and in furtherance of the Company’s compensatory
      benefit plan for participation by the Company’s employees (including officers),
      directors or consultants. Defined terms not explicitly defined in this agreement
      but defined in the Cryoport Systems, Inc. 2002 Stock Incentive Plan (the “Plan”)
      shall have the same definitions as in the Plan.
    
1. Grant
      of Option.
      Subject
      to the vesting provisions of Sections 3 and 4, the Company hereby grants to
      Optionee, as of the date hereof the right and option to purchase, on the terms
      and conditions hereinafter set forth, all or any part of the aggregate number
      of
      shares of Common Shares set forth on the Signature Page attached hereto (the
      “Option”), subject to adjustment in accordance with the provisions of Section 18
      below. The Plan provides for the issuance of Incentive Stock Options (“ISO”).
      Subject to Section 25, it is understood and acknowledged that (a) if the
      Optionee complies with the terms of this Agreement, (b) the Option was
      designated as an ISO at the time of grant and (c) the Optionee is an employee
      of
      the Company at all times from the date of this Agreement through the date which
      is three (3) months prior to the exercise of the Option, the Option is intended
      to be an Incentive Stock Option which will qualify under Section 422(b) of
      the
      Code.
    
2. Purchase
      Price.
      The
      Purchase Price is 100% of the fair market value of the Common Shares at the
      time
      that the Option is granted (110% of such fair market value if the Option is
      granted to a 10% shareholder).
    
3. Right
      to Exercise.
      The
      right to exercise the Option shall vest in accordance with the schedule set
      forth on the Signature Page. Notwithstanding the foregoing, the Option shall
      automatically fully vest (i.e., become exercisable) as to all of the Common
      Shares subject to the Option in the event that a Change in Control (as defined
      in Section 14.4 of the Plan) occurs with respect to the Company, subject to
      the
      limitations set forth in Section 14.4 of the Plan. 
    
4. Securities
      Law Requirements.
      No part
      of the Option shall be exercised if counsel to the Company determines that
      any
      applicable registration requirement under the Securities Act of 1933, as
      amended, or any other applicable requirement of Federal or state law has not
      been met.
    
5. Term
      of Option.
      The
      Option shall terminate in any event on the earliest of (a) the date set forth
      on
      the Signature Page, (b) the expiration of the period described in Section 6
      below, (c) the expiration of the period described in Section 7 below, (d) the
      expiration of the period described in Section 8 below; (e) the expiration of
      the
      period described in Section 9 below; or (f) the expiration of ten (10) years
      (five (5) years in the case of an Option granted to a 10% shareholder) from
      the
      date the Option was granted.
    
6. Exercise
      Following Termination of Employment, Except By Death, Disability or
      Retirement.
      If the
      Optionee’s service with the Company terminates for any reason other than death,
      disability or retirement, the Option (to the extent it has not previously been
      exercised and is then exercisable) may be exercised within the period of thirty
      (30) consecutive days commencing immediately following the date of such
      termination (but not later than the termination date set forth in Section 5(a)
      above). The foregoing notwithstanding, the Option shall cease to be exercisable
      on the date of such termination if the termination is for cause. For this
      purpose, “cause” shall mean conviction of a felony, misappropriation of assets
      of the Company or any subsidiary, continued or repeated insobriety, continued
      or
      repeated absence from service during the usual working hours of the Optionee’s
      position for reason other than disability or sickness, or refusal to carry
      out
      the reasonable directions of the Company’s Board of Directors or senior
      executive officers.
    
7. Exercise
      Following Death.
      If the
      Optionee’s service with the Company terminates by reason of the Optionee’s
      death, or if the Optionee dies after termination of service but while the Option
      would have been exercisable hereunder, the Option (to the extent it has not
      previously been exercised and is then exercisable) may be exercised within
      six
      (6) months after the date of Optionee’s death (but not later than the
      termination date set forth in Section 5(a) above). The exercise may be made
      by
      Optionee’s representative or by the person entitled thereto under Optionee’s
      will or the laws of descent and distribution; provided that such representative
      or such person consents in writing to abide by and be subject to the terms
      of
      this Agreement and such writing is delivered to the President of the
      Company.
    
8. Exercise
      Following Disability.
      If the
      Optionee’s service with the Company terminates by reason of the Optionee’s
      disability, the Option (to the extent not previously exercised and is then
      exercisable) may be exercised for a period of thirty (30) days after the date
      of
      termination for reason of disability (but not later than the termination date
      set forth in Section 5(a) above).
    
9. Exercise
      Following Retirement.
      If the
      Optionee’s service with the Company terminates by reason of retirement, pursuant
      to the Company’s formal retirement policy, the Option (to the extent it has not
      previously been exercised and is then exercisable) may be exercised within
      thirty (30) consecutive days after the date of the Optionee’s retirement (but
      not later than the termination date set forth in Section 5(a)
      above).
    
10. Time
      of Termination of Service.
      For the
      purposes of this Agreement, Optionee’s service shall be deemed to have
      terminated on the earlier of (a) the date when Optionee’s service in fact
      terminated or (b) the date when the Optionee gave or received written notice
      that his or her service is to terminate.
    2
        
11. Nontransferability.
      Unless
      the Company otherwise consents in writing, the Option and all rights and
      privileges granted hereunder shall be non-assignable and non-transferable by
      the
      Optionee, either voluntarily or by operation of law, except by will or by
      operation of the laws of descent and distribution, shall not be pledged or
      hypothecated in any way, and shall be exercisable during lifetime only by the
      Optionee. Except as otherwise provided herein, any attempted alienation,
      assignment, pledge, hypothecation, attachment, execution or similar process,
      whether voluntary or involuntary, with respect to all or any part of the Option
      or any right thereunder, shall be null and void and, at the Company’s option,
      shall cause all of Optionee’s rights under this Agreement to
      terminate.
    
12. Effect
      of Exercise.
      Upon
      exercise of all or any part of the Option, the number of shares of Common Shares
      subject to the Option under this Agreement shall be reduced by the number of
      shares with respect to which such exercise is made.
    
13. Partial
      Exercise.
      Any
      exercisable portion of the Option or the entire Option, if then wholly
      exercisable, may be exercised in whole or in part at any time prior to the
      time
      when the Option or portion thereof becomes unexercisable under Section 5;
      provided, however, that each partial exercise shall be for not less than one
      hundred (100) shares and shall be for whole shares only.
    
14. Method
      of Exercise.
      Each
      exercise of the Option shall be by means of a written notice of exercise in
      substantially the form of attached Exhibit A delivered to the Secretary of
      the
      Company at its principal office and accompanied by payment in full of the option
      price for each share of Common Shares purchased under the Option. Such notice
      shall specify the number of shares of Common Shares with respect to which the
      Option is exercised and shall be signed by the person exercising the Option.
      If
      the Option is exercised by a person other than the Optionee, such notice shall
      be accompanied by proof, reasonably satisfactory to the Company, of such
      person’s right to exercise the Option. 
    
The
      Purchase Price specified in Section 2 above shall be paid in full upon the
      exercise of the Option (i) by cash or check, in United States dollars or (ii)
      in
      any other form determined by the Board of Directors and that is consistent
      with
      applicable laws, rules and regulations. 
    
15. Withholding
      Taxes.
      If the
      Optionee is an employee or former employee of the Company when all or part
      of
      the Option is exercised, unless the Option qualifies as an ISO under Section
      422
      of the Code, the Company may require the Optionee to deliver payment of any
      withholding taxes (in addition to the Option exercise price) in cash with
      respect to the difference between the Option exercise price and the Fair Market
      Value of the Common Shares acquired upon exercise. Alternatively, the Company
      may accept shares having a Fair Market Value equal to the amount of the
      withholding taxes.
    3
        
16. Issuance
      of Shares.
      Subject
      to the foregoing conditions, the Company, as soon as reasonably practicable
      after receipt of a proper notice of exercise and without transfer or issue
      tax
      or other incidental expense to the person exercising the Option, shall deliver
      to such person at the principal office of the Company, or such other location
      as
      may be acceptable to the Company and such person, one or more certificates
      for
      the shares of Common Shares with respect to which the Option has been exercised.
      Such shares shall be fully paid and non-assessable and shall be issued in the
      name of such person. However, at the request of the Optionee, such shares may
      be
      issued in the names of the Optionee and his or her spouse (a) as joint tenants
      with right of survivorship, (b) as community property or (c) as tenants in
      common without right of survivorship.
    
17. Limitation
      of Optionee’s Rights.
      Neither
      Optionee nor any person entitled to exercise the Option shall be or have any
      of
      the rights of a shareholder of the Company in respect of any share issuable
      upon
      the exercise of the Option unless and until a certificate or certificates
      representing shares of Common Shares shall have been issued and delivered upon
      exercise of the Option in full or in part. No adjustment shall be made for
      dividends or other rights for which the record date is prior to the date such
      stock certificates are issued. This Option is not an employment contract and
      nothing in this Option shall be deemed to create in any way whatsoever any
      obligation on Optionee’s part to continue in the employ of the Company, or of
      the Company to continue Optionee’s employment with the Company. In addition,
      nothing in this Option shall obligate the Company or any Affiliate of the
      Company, or their respective shareholders, Board of Directors, officers or
      employees to continue any relationship which Optionee might have as an Outside
      Director or Consultant for the Company or Affiliate of the Company.
    
18.
      Consent
      Required to Transfer.
      In
      connection with any underwritten public offering by the Company of its equity
      securities pursuant to an effective registration statement filed under the
      Securities Act of 1933, as amended, including the Company’s initial public
      offering, Optionee shall not sell, make any short sale of, loan, hypothecate,
      pledge, grant any option for the purchase of, or otherwise dispose or transfer
      for value or otherwise agree to engage in any of the foregoing transactions
      with
      respect to, any shares of Common Shares purchased under the Option without
      the
      prior written consent of the Company or its underwriters. Such limitations
      shall
      be in effect for such period of time from and after the effective date of such
      registration statement as may be requested by the Company or such
      underwriters.
    
19. Recapitalizations.
      Subject
      to the provisions of the Plan, if the outstanding shares of the class then
      subject to this Option are adjusted for any increase or decrease in the number
      of issued shares of Common Shares resulting from a subdivision or consolidation
      of Common Shares or the payment of a stock dividend (but only of Common Shares)
      or any other increase or decrease in the number of issued shares of Common
      Shares effected without receipt of consideration by the Company, appropriate
      adjustments shall be made in the number and/or kind of shares or securities
      for
      which the unexercised portions of this Option may thereafter be exercised,
      all
      without any change in the aggregated exercise price applicable to the
      unexercised portions of this Option, but with a corresponding adjustment in
      the
      exercise price per share or other unit. Subject to the provisions of the Plan,
      if the Company is the surviving corporation in any merger or consolidation,
      this
      Option shall pertain and apply to the securities to which a holder of the number
      of Common Shares subject to the Option would have been entitled. In the event
      of
      a merger or consolidation in which the Company is not the surviving corporation,
      the date of exercisability of this Option shall be accelerated to a date prior
      to such merger or consolidation, unless the agreement of merger or consolidation
      provides for the assumption of the Option by the successor to the Company.
      To
      the extent that the foregoing adjustments relate to securities of the Company,
      such adjustments shall be made by the Board, whose determination shall be
      conclusive and binding on all persons. Except as expressly provided in this
      Section 19, the Optionee shall have no rights by reason of subdivision or
      consolidation of shares of any class, the payment of any Common Share dividend
      or any other increase or decrease in the number of shares of any class or by
      reason of any dissolution, liquidation, merger or consolidation or spin-off
      of
      assets or shares of another corporation, and any issue by the Company of shares
      of any class, or securities convertible into shares of any class, shall not
      affect, and no adjustment by reason thereof shall be made with respect to,
      the
      number or Purchase Price of Common Shares subject to this Option. 
    4
        
20. Restricted
      Stock Provisions.
      In
      addition to certain Federal and state securities laws restrictions, until such
      time as the Company shall have consummated an initial public offering of its
      Common Shares, the shares of Common Shares issued on exercise of this Option
      shall upon issuance be subject to the following restrictions (and, as used
      herein, “restricted stock” means shares issued on exercise of this Option which
      are still subject to the restrictions imposed under this Section that have
      not
      yet expired or terminated):
    
(a) Such
      shares of restricted stock may not be sold or otherwise transferred or
      hypothecated;
    
(b) If
      the
      employment of the Optionee with the Company or a subsidiary of the Company
      is
      terminated for any reason, other than his or her death, normal or early
      retirement in accordance with his or her employer’s established retirement
      policies and practices, or total disability, the Company (or any subsidiary
      designated by it) shall have the option for sixty (60) days after such
      termination of employment to purchase for cash all or any part of his or her
      restricted stock at the Fair Market Value of the restricted stock on the date
      of
      such termination of employment (for which purpose Fair Market Value shall have
      the same meaning as set forth in the Plan);
    
(c) The
      restrictions imposed under Section 20 shall apply as well to all shares or
      other
      securities issued in respect of restricted stock in connection with any stock
      split, reverse stock split, stock dividend, recapitalization, reclassification,
      spin-off, split-off merger, consolidation or reorganization, but such
      restrictions imposed under Section 20 shall expire or terminate on the earliest
      to occur of the following:
    
(i) The
      ninetieth (90th)
      day
      after the date on which shares of the same class of Common Shares as such
      restricted stock first become publicly traded;
    
(ii) The
      fifth
      (5th)
      anniversary of the date of grant hereof;
    5
        
(iii) As
      to any
      shares for which the Company’s (or a subsidiary’s) sixty (60) day option to
      purchase upon termination of employment shall have become exercisable but shall
      expire without having been exercised, on the first business day of the calendar
      month next following the expiration of such sixty (60) day option period;
      or
    
(iv) The
      occurrence of any event or transaction upon which this Option terminated by
      reason of the provisions of Section 19 hereof.
    
(d) All
      certificates representing shares of Common Shares purchased upon the exercise
      of
      the Option shall bear the following legends:
    
“THE
      SALE OF THE SECURITIES REPRESENTED HEREBY HAS NOT BEEN REGISTERED UNDER THE
      SECURITIES ACT OF 1933, AS AMENDED (THE “ACT”). ANY TRANSFER OF SUCH SECURITIES
      WILL BE INVALID UNLESS A REGISTRATION STATEMENT UNDER THE ACT IS IN EFFECT
      AS TO
      SUCH TRANSFER OR IN THE OPINION OF COUNSEL FOR THE ISSUER SUCH REGISTRATION
      IS
      UNNECESSARY IN ORDER FOR SUCH TRANSFER TO COMPLY WITH THE
      ACT.”
    
21. Stock
      Incentive Plan.
      This
      Agreement is subject to, and the Company and the Optionee agree to be bound
      by,
      all of the terms and conditions of the Company’s 200_ Stock Incentive Plan under
      which this Option was granted, as the same shall have been amended from time
      to
      time in accordance with the terms thereof, provided that no such amendment
      shall
      deprive the Optionee, without his or her consent, of this Option or any of
      his
      or her rights hereunder. Pursuant to said Plan, the Board of Directors of the
      Company or its Committee established for such purposes is vested with final
      authority to interpret and construe the Plan and this Option, and is authorized
      to adopt rules and regulations for carrying out the Plan. A copy of the Plan
      in
      its present form is available for inspection during business hours by the
      Optionee or other persons entitled to exercise this Option at the Company’s
      principal office.
    
22. Notices.
      Any
      notice to the Company contemplated by this Agreement shall be addressed to
      it in
      care of its President; any notice to the Optionee shall be addressed to him
      or
      her at the address on file with the Company on the date hereof or at such other
      address as Optionee may hereafter designate in a writing delivered to the
      Company as provided herein.
    
23. Interpretation.
      The
      interpretation, construction, performance and enforcement of this Agreement
      shall lie within the sole discretion of the Board, and the Board’s
      determinations shall be conclusive and binding on all interested
      persons.
    
24. Governing
      Law.
      This
      Agreement has been made, executed and delivered in, and the interpretation,
      performance and enforcement hereof shall be governed by and construed under
      the
      laws of the State of California.
    6
        
25. Effect
      of Early Disposition.
      If the
      Optionee exercises an Option granted as an ISO within two (2) years of the
      date
      on which the Option was granted, or disposes of the stock obtained by the
      exercise of the Option within one (1) year from the date of such exercise,
      whichever is later, the Option will be a Nonqualified Stock Option, and the
      gain, if any, on exercise will be treated as compensation rather than as capital
      gain. The Optionee agrees to notify the Company of such early exercise of the
      Option or disposition of the stock acquired within thirty (30) days thereof.
      Optionee shall not be required to hold the Common Shares for any period of
      time
      following exercise, unless legal counsel to the Company shall reasonably
      determine that such a sale would violate federal or state securities laws.
      
    ********************
    7
        SIGNATURE
      PAGE
    INCENTIVE
      STOCK OPTION AGREEMENT
    PURSUANT
      TO
    CRYOPORT
      SYSTEMS, INC.
    2002
      STOCK INCENTIVE PLAN
    | Date of Grant: | ______________________________ | 
| Exercise Price: | ______________________________ | 
| Number of Shares: | ______________________________ | 
| Vesting Schedule: | ______________________________ | 
| ______________________________ | |
| ______________________________ | |
| ______________________________ | |
| ______________________________ | 
Notwithstanding
      the foregoing, the Option shall automatically fully vest upon a Change in
      Control (as defined in Section 14.4 of the Plan), subject to the limitations
      set
      forth in Section 14.4 of the Plan.
    
Expiration
      Date:      
    
I
      have
      read the Incentive Stock Option Agreement indicated above which was adopted
      for
      use in connection with the 2002 Stock Incentive Plan. I have also received
      and
      reviewed a copy of the 2002 Stock Incentive Plan. As Optionee, I hereby
      acknowledge that as of the date of grant of this option, it sets forth the
      entire understanding between the undersigned Optionee and the Company and its
      Affiliates regarding the acquisition of stock in the Company and supersedes
      all
      prior oral and written agreements on that subject with the exception of (i)
      the
      options and any other stock awards previously granted and delivered to the
      undersigned under stock award plans of the Company, and (ii) the following
      agreements only:
    
NONE
      _________ 
    (Initial)
    OTHER
      ___________________________________________________________________
    8
        
IN
      WITNESS WHEREOF, this Incentive Stock Option Agreement has been delivered by
      the
      parties hereto.
    | Date: ______________________ | "Optionee" | 
| _________________________________ | |
| Name _________________________________ | |
| Address _______________________________ | |
| ______________________________________ | |
| _________________________________ | |
| Social Security Number _________________ | 
The
        Company hereby agrees to
      all
        the
        terms of the Agreement.
      Cryoport
        Systems, Inc.
      By:
        ___________________________________
      Name:
        _________________________________
      Title:
          __________________________________
        9
        EXHIBIT
      A
    OPTION
      EXERCISE FORM
    (To
      be
      executed only upon exercise of Option)
    
The
      undersigned holder of the Option hereby irrevocably exercises the Option for
      the
      purchase of that number of shares of the Common Shares, no par value, of
      CRYOPORT SYSTEMS, INC. set forth below, up to a maximum of __________ shares
      (or
      such other number of shares as may be issuable upon the exercise of the Option
      pursuant to the adjustment provisions of the Agreement), and hereby makes
      payment of the aggregate Purchase Price therefore which is also set forth below,
      all on the terms and subject to the conditions specified in this
      Agreement.
    | Number of Shares: | __________________ | 
| x | |
| Exercise Price: | $_________________ | 
| Aggregate Exercise Price Paid: | $_________________ | 
Dated: _________________________
| HOLDER: | |
| ___________________________ | |
| (Signature) | |
| ___________________________ | |
| (Please print) | 
ACCEPTED:
      CRYOPORT
        SYSTEMS, INC.
      By:
          ___________________________________
        Name:
          _________________________________
        Title:
            __________________________________