Exhibit 99.1 

Cryoport Reports Fourth Quarter and Full Year 2021 Results

NASHVILLE, Tennessee, February 24, 2022 - Cryoport, Inc. (NASDAQ: CYRX) (“Cryoport” or the “Company”), a global leader in temperature-controlled supply chain solutions for the life sciences industry, today announced financial results for the three months and year ended December 31, 2021.

Jerrell Shelton, CEO of Cryoport, commented, “Last year was an important year for Cryoport. Our total revenue grew to a record $222.6 million driven by strong performance by MVE Biological Solutions and CRYOPDP as well as significant organic revenue growth of 40% from Cryoport Systems and CRYOGENE. In our first full year following the transformational acquisitions of MVE Biological Solutions and CRYOPDP, we firmly established Cryoport as a global market leader for comprehensive supply chain solutions for the life sciences industry. And we sharpened our focus on the rapidly growing Cell & Gene Therapy market with an expanding platform of products, services, systems, and solutions. Our overall pipeline of business continues to strengthen with Cryoport Systems now supporting a record 602 clinical trials and 8 commercial therapies globally. To meet our strong and accelerating demand, we have expanded our global network to 33 facilities in 15 countries, strengthened our presence in the high growth APAC and EMEA regions, and completed preparations for the upcoming opening of our first two new Global Supply Chain Centers in the United States. We closed 2021 in the strongest position in our company’s history, with $629 million in cash and short-term investments to support our organic growth as well as provide us with the ability to complete future acquisitions.

“Notwithstanding the global supply chain challenges, fourth quarter revenue reached $56.4 million, an increase of 17% year-over-year. This performance was driven by strong organic year-over-year revenue growth of 34% from Cryoport Systems and CRYOGENE, and a solid performance from CRYOPDP and MVE Biological Solutions despite third-party shipping delays that caused approximately $2.0 million of MVE’s revenue to shift to the first quarter of 2022. Throughout 2021, our teams continued to execute and perform at a very high level across all business units.

“On January 25, 2022, a fire occurred in a portion of MVE Biological Solutions’ New Prague manufacturing facility. The fire caused a curtailment of activity for approximately three weeks, but production has resumed and is now ramping. We expect the revenue impact to be between $4 million and $5 million and to be limited to the first quarter of 2022. Currently, demand for MVE Biological Solutions’ products and systems is at an all-time high and plans are underway to further increase capacities in both United States manufacturing plants.

“Our Biopharma/Pharma revenue increased 18% year-over-year in the fourth quarter of 2021, while Biopharma/Pharma revenue for Cryoport Systems and CRYOGENE grew 38%, demonstrating continued strong traction in the Cell & Gene Therapy market. We now support a record 602 clinical trials, compared with 582 at the end of the third quarter of 2021 and 528 at the end of the fourth quarter of 2020. We also support eight commercial therapies in regenerative medicine, including Novartis’ KYMRIAH^®, Gilead/Kite’s YESCARTA^® and TECARTUS^®, bluebird bio’s ZYNTEGLO™ and SKYSONA™, Bristol Myers Squibb’s BREYANZI^® and ABECMA^® and Orchard Therapeutics’ LIBMELDY™.

“Our revenue by market for the three months and year ended December 31, 2021, as compared to the same periods in 2020 was as follows:

Cryoport, Inc. and Subsidiaries

Total revenues by market

(unaudited)

Mr. Shelton concluded, “The rapidly growing Cell & Gene Therapy market we serve is still in its formative stages and demand for our systems and solutions continues to accelerate. We now support many of the world’s leading life sciences companies with mission-critical supply chain solutions as they endeavor to bring their therapies through clinical trials to the commercial market and ultimately patient populations worldwide. As the therapies we support advance through the clinical stages, we anticipate a growing number of commercial opportunities to emerge, bolstering our long-term outlook for revenue growth and market share gains. We plan to further strengthen our leadership position with a primary focus on service, innovation, and expansion in key markets throughout the world.”

Total Biopharma/Pharma revenue represents over 80% of Cryoport’s total revenue and increased by $7.0 million, or 18%, to $46.3 million for the fourth quarter of 2021 compared to $39.3 million for the fourth quarter of 2020, driven by strong revenue contributions from all business units. For the fourth quarter of 2021, Biopharma/Pharma revenue for Cryoport Systems and CRYOGENE grew by $4.2 million, or 38%, to $15.2 million compared to fourth quarter of 2020 demonstrating continued maturation of Cryoport’s position within the regenerative medicine market.

As of December 31, 2021, the Company supported a net total of 602 clinical trials, a net increase of 20 clinical trials during the fourth quarter of 2021 and 74 clinical trials for the year. The number of trials by phase and region are as follows:

A total of eleven (11) Cryoport supported Biologic License Applications (BLAs) or Marketing Authorization Applications (MAAs) were filed in 2021, based on internal information and data from the Alliance for Regenerative Medicine, of which two (2) were filed during the fourth quarter of 2021. During 2022, we anticipate up to an additional nineteen (19) filings, (4) new therapy approvals, and an additional six (6) label or geographic expansion approvals.

Our commercial Cell & Gene Therapy clients continued to expand during 2021, including:

Novartis filed in the United States, Europe, and Japan to expand the use of KYMRIAH^® into follicular lymphoma. Currently KYMRIAH^® is approved to treat third line diffuse large B-cell lymphoma (DLBCL) and acute lymphoblastic leukemia (ALL).

Gilead/Kite filed, and was granted Priority Review by the FDA, for a supplemental biologic license application in the United States to move YESCARTA^® from a third line to a second line treatment for DLBCL with an upcoming expected regulatory decision on April 1, 2022. Gilead also made regulatory submissions with the European Medicines Agency (“EMA”) and expects to receive notice in the second half of 2022. YESCARTA^® is also currently approved for the treatment of follicular lymphoma.

Bristol Myers Squibb (BMS) also had significant commercial news in 2021 as BREYANZI^® was approved in the United States for third line DLBCL and ABECMA^® became the world’s first CAR-T therapy to be approved for the treatment for multiple myeloma. Recently, BMS announced that ABECMA^® has also been approved in Japan and that they expect data in 2022 to support the move of ABECMA^® from a fifth line treatment to a second line treatment. On February 17^th, 2022, BMS announced that their supplemental BLA has been accepted by the FDA to move BREYANZI^® from a third line to a second lined treatment for DLBCL. BMS has also secured a priority review of the supplemental BLA from the FDA and expects a regulatory decision by June 24^th, 2022.

Financial Highlights

Note: All reconciliations of GAAP to adjusted (non-GAAP) figures above are detailed in the reconciliation tables included later in the press release.

Further information on Cryoport’s financial results is included in the attached condensed consolidated balance sheets and statements of operations, and additional explanations of Cryoport’s financial performance are provided in Cryoport’s Annual Report on Form 10-K for the year ended December 31, 2021, which is expected to be filed with the Securities and Exchange Commission (“SEC”) on or before March 1, 2022. The full report will be available on the SEC Filings section of the Investor Relations section of Cryoport’s website at www.cryoport.com.

Earnings Conference Call Information

IMPORTANT INFORMATION: A document titled “Cryoport Fourth Quarter and Full Year 2021 In Review”, providing a review of Cryoport’s recent financial and operational performance and a general business update, will be issued at 4:05 p.m. EDT on Thursday, February 24, 2022. The document is designed to be read by investors before the questions and answers conference call and will be accessible at: http://ir.cryoport.com/events-and-presentations.

Cryoport management will host a conference call at 5:00 p.m. EDT on February 24, 2022. The conference call will be in the format of a questions and answers session and will address any queries investors have regarding the Company’s reported results. A slide deck will accompany the call.

Conference Call Information

Questions and answers will be recorded and available approximately three hours after completion of the live event on the Investor Relations section of the Company's website at www.cryoport.com for a limited time. To access the replay of the questions and answers, please follow this link. A dial-in replay of the call will also be available to those interested, until 11:59 p.m. ET on March 3, 2022. To access the replay, dial +1 844-512-2921 (United States) or +1 412-317-6671 (International) and enter replay pin number: 13726525.

About Cryoport, Inc.

Cryoport, Inc. (Nasdaq: CYRX), headquartered in Nashville, TN, is a global leader in temperature-controlled supply chain solutions for the life sciences industry supporting life-saving cell and gene therapies across the clinical and commercial spectrum. With 33 strategic locations covering the Americas, EMEA (Europe, the Middle East and Africa) and APAC (Asia Pacific), Cryoport’s global platform provides mission-critical solutions, services, and products to Biopharma, Animal Health, and Reproductive Medicine customers worldwide. In addition to its standard setting supply chain solutions, Cryoport is the world’s largest manufacturer of cryogenic systems and one of the largest life science focused specialty couriers. As of December 31, 2021, Cryoport supported eight commercial cell and gene therapies and 602 regenerative medicine clinical trials globally, with 74 of these trials in Phase 3.

For more information, visit www.cryoport.com or follow @cryoport on Twitter at www.twitter.com/cryoport for live updates.

Forward-Looking Statements

Statements in this press release which are not purely historical, including statements regarding the Company’s intentions, hopes, beliefs, expectations, representations, projections, plans or predictions of the future, are forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. These forward-looking statements include, but are not limited to, those related to the Company’s industry, business, plans, strategy, acquisitions, future financial results and financial condition, projected trends in the market in which the Company operates, expected impact of the New Prague facility fire, and regulatory approvals with respect to the products of the Company’s clients. It is important to note that the Company’s actual results could differ materially from those in any such forward-looking statements. Factors that could cause actual results to differ materially include, but are not limited to, risks and uncertainties associated with the effect of changing economic conditions, including as a result of the COVID-19 pandemic and its variants, trends in the products markets, variations in the Company’s cash flow, market acceptance risks, and technical development risks. The Company’s business could be affected by a number of other factors, including the risk factors discussed in the Company’s Securities and Exchange Commission (“SEC”) reports including, but not limited to, the Company’s Annual Report on Form 10-K for the year ended December 31, 2021, and any subsequent filings with the SEC. The forward-looking statements contained in this press release speak only as of the date hereof and the Company cautions investors not to place undue reliance on these forward-looking statements. Except as required by law, the Company disclaims any obligation, and does not undertake to update or revise any forward-looking statements in this press release.

Cryoport Investor Contacts:

Todd Fromer

KCSA Strategic Communication

tfromer@kcsa.com

P: 1-212-896-1203

Cryoport, Inc. and Subsidiaries

Condensed Consolidated Statements of Operations

(unaudited)

Note Regarding Use of Non-GAAP Financial Measures

This news release contains the following non-GAAP financial measures as defined in Regulation G of the Securities Exchange Act of 1934: adjusted EBITDA, organic revenue, and organic revenue growth.

Adjusted EBITDA is defined as net loss adjusted for interest expense, income taxes, depreciation and amortization expense, stock-based compensation expense, acquisition and integration costs, investment income, and charges or gains resulting from non-recurring events, including loss on extinguishment of debt.

Organic revenue is a change in revenue adjusted for acquisitions of businesses that occurred on or after January 1, 2020. To present period-over-period organic revenues on a comparable basis, revenues are adjusted to include only revenues from those businesses and assets owned during the entirety of both periods. Accordingly, organic revenue excludes revenues attributable to each such acquisition subsequent to the day of acquisition, as there are no revenues from those businesses and assets for the entire comparable prior period.

Organic revenue growth refers to the measure of comparing current period organic revenue with the corresponding period of the prior year.

These non-GAAP financial measures are not calculated in accordance with generally accepted accounting principles (GAAP), are not based on any comprehensive set of accounting rules or principles and may be different from non-GAAP financial measures presented by other companies. Non-GAAP financial measures, including adjusted EBIDTA, organic revenue, and organic revenue growth, should not be considered as a substitute for, or superior to, measures of financial performance prepared in accordance with GAAP.

In evaluating Cryoport's performance, management uses these non-GAAP financial measures to supplement financial statements prepared under GAAP. Management believes adjusted EBITDA provides a useful measure of Cryoport's operating results, a meaningful comparison with historical results and with the results of other companies, and insight into Cryoport's ongoing operating performance. Further, management and the Board of Directors utilize adjusted EBITDA to gain a better understanding of Cryoport's comparative operating performance from period-to-period and as a basis for planning and forecasting future periods. Management believes adjusted EBITDA, when read in conjunction with Cryoport's GAAP financials, is useful to investors because it provides a basis for meaningful period-to-period comparisons of Cryoport's ongoing operating results, including results of operations, against investor and analyst financial models, identifying trends in Cryoport's underlying business and performing related trend analyses, and it provides a better understanding of how management plans and measures Cryoport's underlying business.

Additionally, management believes organic revenue and organic revenue growth provide a useful measure to assess the performance of Cryoport and its business units without the impact of recent acquisitions. Management believes organic revenue and organic revenue growth, when read in conjunction with Cryoport's GAAP financials, are useful to investors because they provide a basis for meaningful period-to-period comparisons of Cryoport's revenues.

Cryoport, Inc. and Subsidiaries

Reconciliation of GAAP net loss to adjusted EBITDA

(unaudited)

Cryoport, Inc. and Subsidiaries

Organic revenue growth (non-GAAP) by market

(unaudited)  

Cryoport, Inc. and Subsidiaries

Organic revenue growth (non-GAAP) by market

(unaudited)

Note: Organic revenue refers to Cryoport Systems and CRYOGENE. Acquisitions include CRYOPDP and MVE Biological Solutions acquired in October 2020.