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Published on August 27, 2008
CRYOPORT,
INC.
    20382
Barents Sea Circle
    Lake
Forest, California 92630
    August
27, 2008
    VIA FACSIMILE (202-772-9369)
AND EDGAR
    United
States Securities and Exchange Commission
    100 F
Street, N.E.
    Washington,
D.C. 20549
    
Attention:  Dorine
H. Miller
    Re:          Cryoport,
Inc.
    Registration Statement on Form
S-1
    File
No. 333-152329
    Ladies
and Gentlemen:
    Pursuant to Rule 461 of the General
Rules and Regulations under the Securities Act of 1933, as amended (the “Act”),
Cryoport, Inc. (the “Company”) respectfully requests that the effective date of
the registration statement referred to above be accelerated so that it will
become effective at 11.00 a.m., Eastern Time, Thursday, August 28, 2008, or as
soon thereafter as possible.
    We hereby
acknowledge the following:
    | ·   | that
      should the Commission or the staff, acting pursuant to delegated
      authority, declare the filing effective, it does not foreclose the
      Commission from taking any action with respect to the
    filing; | 
| ·   | the
      action of the Commission or the staff, acting pursuant to delegated
      authority, in declaring the filing effective, does not relieve the Company
      from its full responsibility for the adequacy and accuracy of the
      disclosure in the filing; and | 
| ·   | the
      Company may not assert staff comments and the declaration of effectiveness
      as a defense in any proceeding initiated by the Commission or any person
      under the federal securities laws of the United
  States. | 
CRYOPORT, INC.
    By:  /s/ Peter
Berry
    Name: Peter Berry
    Title:  Chief Executive
Officer